ChemicalBook CAS DataBase List 1-METHYL-2-INDOLINONE

1-METHYL-2-INDOLINONE synthesis

14synthesis methods

Product Name:1-METHYL-2-INDOLINONE
CAS Number:61-70-1
Molecular formula:C9H9NO
Molecular Weight:147.17

603-76-9
418 suppliers
$18.00/5g

61-70-1
129 suppliers
$10.00/250mg

Yield:61-70-1 92%

Reaction Conditions:

with water;iodine in N,N-dimethyl-formamide at 120; for 12 h;Solvent;Reagent/catalyst;

Steps:

1.15
General procedure: 1 mmol of 1-methylindole was added to a 10 mL round bottom flask, followed by 1 mL of N,N-dimethylformamide (DMF).2mL water and 0.5mmol elemental iodine (I2),Heat to 120 ° C,The reaction was refluxed under air for 12 hours.After cooling, 10 mL of 10% Na2S2O3 was added to the reaction system.10 mL of saturated NaHCO3, extracted with 3×10 mL ethyl acetate.After drying anhydrous sodium sulfate, the solvent is recovered.Silica gel column chromatography gave a pale yellow solid which was 1-methylindole-2-one.

References:

Chinese Academy Of Sciences Chengdu Organic Chemistry Co., Ltd.;University of the Chinese Academy of Sciences;Rong Guangqing;Zhao Jianqiang CN108658835, 2018, A Location in patent:Paragraph 0040; 0042; 0045

59-48-3 Synthesis