![](/CAS/GIF/113028-17-4.gif)
Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate synthesis
- Product Name:Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
- CAS Number:113028-17-4
- Molecular formula:C18H20FN3O3S
- Molecular Weight:377.43
![Piperazine](/CAS/GIF/110-85-0.gif)
110-85-0
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![Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate](/CAS/GIF/113046-72-3.gif)
113046-72-3
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![Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate](/CAS/GIF/113028-17-4.gif)
113028-17-4
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$83.00/100mg
Yield: 87%
Reaction Conditions:
in dimethyl sulfoxide at 60; for 4 h;
Steps:
1 Preparation of ethyl 6-fluoro-7-piperazine-1-methyl-4-oxo- [1,3] thiazacyclo [3,2-a] quinoline-3-carboxylate
50 g of ethyl 6,7-difluoro-1-methyl-4-oxo-4H- [1,3] thiazine [3,2-a] Dissolve in 5 volumes of DMSO at 60°C, add 40 g of piperazine, and stir at 60°C for 4 hours. The mixture was cooled to room temperature, then 5 volumes of acetonitrile were added and stirring was continued for 4 hours at room temperature. The precipitate was collected by filtration and dried to give 6-fluoro-7-piperazine-1-methyl-4-oxo- [1,3] thiazacyclo [3,2-a] Ethyl acid 52.8g, yield 87%. The yield of 6-fluoro-7-piperazine-1-methyl-4-oxo- [1,3] thiazacyclo [3,2-a] quinoline-3-carboxylic acid B Ester purity 99%.
References:
Zhaoke Pharmaceutical (Hefei) Co., Ltd.;Li Xiaoyi;Dai Xiangrong;Zhou Guanqun CN107383069, 2017, A Location in patent:Paragraph 0061; 0062
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113028-75-4
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113028-17-4
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$83.00/100mg
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144514-15-8
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![Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate](/CAS/GIF/113028-17-4.gif)
113028-17-4
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$83.00/100mg
![3,4-Difluoroaniline](/CAS/GIF/3863-11-4.gif)
3863-11-4
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113028-17-4
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$83.00/100mg
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84339-06-0
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![Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate](/CAS/GIF/113028-17-4.gif)
113028-17-4
94 suppliers
$83.00/100mg