Cyclobutanecarboxylic acid, 1-amino-, phenylmethyl ester (9CI) synthesis

5synthesis methods

Product Name:Cyclobutanecarboxylic acid, 1-amino-, phenylmethyl ester (9CI)
CAS Number:125483-56-9
Molecular formula:C12H15NO2
Molecular Weight:205.25

Benzyl-1-(tert-butoxycarbonyl)cyclobutanecarboxylate

1164340-01-5
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Cyclobutanecarboxylic acid, 1-amino-, phenylmethyl ester (9CI)

125483-56-9
13 suppliers
$311.00/1g

Yield:125483-56-9 91%

Reaction Conditions:

Stage #1: benzyl 1-(tert-butoxycarbonylamino)cyclobutanecarboxylatewith trifluoroacetic acid in dichloromethane at 20; for 1 h;
Stage #2: with hydrogenchloride in diethyl ether;

References:

Bremner, John B.;Keller, Paul A.;Pyne, Stephen G.;Robertson, Mark J.;Sakthivel;Somphol, Kittiya;Baylis, Dean;Coates, Jonathan A.;Deadman, John;Jeevarajah, Dharshini;Rhodes, David I. [Beilstein Journal of Organic Chemistry,2012,vol. 8,p. 1265 - 1270] Location in patent:supporting information; experimental part

22264-50-2 Synthesis