2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one hydrochloride synthesis

3synthesis methods

Product Name:2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one hydrochloride
CAS Number:1312412-89-7
Molecular formula:C6H8ClN3OS
Molecular Weight:205.66

1312412-88-6 Synthesis

2-AMino-4-oxo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylic acid tert-butyl ester

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2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one hydrochloride

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Yield:1312412-89-7 95%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 0.5 h;

Steps:

A4

A solution of intermediate 3 (15 g, 55.6 mmol) in a 4M solution of HCl in 1,4-dioxane (100 mL,) was stirred at room temperature for 30 minutes. The solvent was evaporated in vacuo to yield 10 g (95%) of intermediate 4 as a yellow powder which was used in the next step without further purification.

References:

WO2011/73347,2011,A1 Location in patent:Page/Page column 33

TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

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1312412-87-5 Synthesis

3-BroMo-2,4-dioxo-piperidine-1-carboxylic acid tert-butyl ester

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References