7-({2-[(1-Methyl-buta-1,3-dienyl)-phenyl-aMino]-pyriMidine-5-carbonyl}-aMino)-heptanoic acid Methyl ester synthesis

7synthesis methods

Product Name:7-({2-[(1-Methyl-buta-1,3-dienyl)-phenyl-aMino]-pyriMidine-5-carbonyl}-aMino)-heptanoic acid Methyl ester
CAS Number:1316216-07-5
Molecular formula:C25H28N4O3
Molecular Weight:432.51

39979-08-3
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2-Diphenylamino-pyrimidine-5-carboxylic acid

1316216-06-4
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7-({2-[(1-Methyl-buta-1,3-dienyl)-phenyl-aMino]-pyriMidine-5-carbonyl}-aMino)-heptanoic acid Methyl ester

1316216-07-5
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Yield:1316216-07-5 54%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine;HATU in tetrahydrofuran at 20;

Steps:

1

A mixture of compound 4 (2.5 g, 8.58 mmol), aminoheptanoate 5 (2.52 g, 12.87 mmol), HATU (3.91 g, 10.30 mmol), DIPEA (4.43 g, 34.32 mmol) was stirred at rt overnight. After the reaction mixture was filtered, the filtrate was evaporated to dryness and the residue was purified by silica gel chromatography (petroleum ethers/EtOAc = 2/1) to give a brown solid(2 g, 54 %).

References:

WO2011/91213,2011,A2 Location in patent:Page/Page column 73; 75

89793-12-4 Synthesis