ChemicalBook CAS DataBase List (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide synthesis

6synthesis methods

Product Name:(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
CAS Number:1346133-11-6
Molecular formula:C24H22F2N2O2
Molecular Weight:408.44

676494-56-7 Synthesis

676494-56-7
20 suppliers
inquiry

920274-04-0 Synthesis

920274-04-0
60 suppliers
$112.00/100mg

(S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

1346133-11-6
28 suppliers
inquiry

Yield:1346133-11-6 46%

Reaction Conditions:

Stage #1: 3-fluoro-4-(4-formylphenoxy)benzamide;(2S)-2-(3-fluorophenyl)pyrrolidine in 1,2-dichloro-ethane at 20; for 20 h;Molecular sieve;
Stage #2: with sodium tris(acetoxy)borohydride;acetic acid in 1,2-dichloro-ethane at 20; for 3 h;

References:

Zhang, Ying;Yan, Qiaozhi;Zi, Guofu;Hou, Guohua [Organic Letters,2017,vol. 19,# 16,p. 4215 - 4218] Location in patent:supporting information

1073-06-9 Synthesis