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ChemicalBook CAS DataBase List LY2828360

LY2828360 synthesis

6synthesis methods
109-01-3 Synthesis
1-Methylpiperazine

109-01-3
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Benzamide, 2-chloro-N-[4-chloro-2-methyl-6-[(tetrahydro-2H-pyran-4-yl)amino]-5-pyrimidinyl]-

1231221-35-4
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Yield:1231220-79-3 92.2%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in i-Amyl alcohol at 160; for 58 h;Large scale;

References:

Debaillie, Amy C.;Jones, Chauncey D.;Laurila, Michael E.;Magnus, Nicholas A.;Staszak, Michael A. [Organic Process Research and Development,2013,vol. 17,# 2,p. 231 - 238]

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