ChemicalBook CAS DataBase List 8-chloro-2-phenyl-3-(1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one

8-chloro-2-phenyl-3-(1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one synthesis

8synthesis methods

Product Name:8-chloro-2-phenyl-3-(1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one
CAS Number:1350643-73-0
Molecular formula:C27H25ClN6O2
Molecular Weight:500.98

1350643-72-9
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6-CHLORO-9-(TETRAHYDRO-2-PYRANYL)-PURINE

7306-68-5
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8-chloro-2-phenyl-3-(1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one

1350643-73-0
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Yield:1350643-73-0 94%

Reaction Conditions:

with triethylamine in isopropyl alcohol at 80; for 24 h;Product distribution / selectivity;

Steps:

5A

Example 5ACompound 9 (2.39 kg) was treated with Compound 4 and triethylamine in isopropyl alcohol at 80° C. for 24 hours. The reaction was monitored by HPLC until completion, affording 8-chloro-2-phenyl-3-((1S)-1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)ethyl)isoquinolin-1(2H)-one (compound 10) as a tan solid in 94% yield with 98% (AUC) purity by HPLC analysis.

References:

US2012/184568,2012,A1 Location in patent:Page/Page column 82

21327-86-6 Synthesis