Ethyl 2-(2-ethyl-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetate synthesis

4synthesis methods

Product Name:Ethyl 2-(2-ethyl-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetate
CAS Number:1414797-93-5
Molecular formula:C17H22O4
Molecular Weight:290.35

2-Naphthaleneacetic acid, 1,2,3,4-tetrahydro-6-methoxy-1-oxo-, ethyl ester

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Ethyl 2-(2-ethyl-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

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Yield:1414797-93-5 90%

Reaction Conditions:

Stage #1: 6-methoxy-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid, ethyl esterwith sodium hydride in N,N-dimethyl-formamide; for 0.166667 h;Cooling with ice;
Stage #2: ethyl iodide in N,N-dimethyl-formamide at 25; for 5 h;

References:

Cheung, Mui;Tangirala, Raghuram S.;Bethi, Sridhar R.;Joshi, Hemant V.;Ariazi, Jennifer L.;Tirunagaru, Vijaya G.;Kumar, Sanjay [ACS Medicinal Chemistry Letters,2018,vol. 9,# 2,p. 103 - 108] Location in patent:supporting information

1078-19-9 Synthesis

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2-(6-Methoxy-1-oxo-3,4-dihydronaphthalen-2(1H)-ylidene)acetic acid

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17529-16-7 Synthesis

6-METHOXY-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL)ACETIC ACID

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References