ChemicalBook CAS DataBase List 2-(3,4-DIMETHOXY-PHENYL)-5,7-DIHYDROXY-3-METHOXY-CHROMEN-4-ONE

2-(3,4-DIMETHOXY-PHENYL)-5,7-DIHYDROXY-3-METHOXY-CHROMEN-4-ONE synthesis

4synthesis methods

Product Name:2-(3,4-DIMETHOXY-PHENYL)-5,7-DIHYDROXY-3-METHOXY-CHROMEN-4-ONE
CAS Number:14549-84-9
Molecular formula:C18H16O7
Molecular Weight:344.32

55317-02-7 Synthesis

2-METHOXY-1-(2,4,6-TRIHYDROXYPHENYL)ETHANONE

55317-02-7
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24824-54-2 Synthesis

24824-54-2
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2-(3,4-DIMETHOXY-PHENYL)-5,7-DIHYDROXY-3-METHOXY-CHROMEN-4-ONE

14549-84-9
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Yield:14549-84-9 74%

Reaction Conditions:

Stage #1: 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone;3,4-dimethoxybenzoic anhydridewith triethylamine for 0.0833333 h;Heating;Allan-Robinson condensation;
Stage #2: with potassium hydroxide in methanol; for 0.333333 h;sonication;

References:

Daskiewicz, Jean-Baptiste;Depeint, Flore;Viornery, Lionel;Bayet, Christine;Comte-Sarrazin, Geraldine;Comte, Gilles;Gee, Jennifer M.;Johnson, Ian T.;Ndjoko, Karine;Hostettmann, Kurt;Barron, Denis [Journal of Medicinal Chemistry,2005,vol. 48,# 8,p. 2790 - 2804]

117-39-5 Synthesis