7-hydroxy-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylic acid synthesis

10synthesis methods

Product Name:7-hydroxy-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylic acid
CAS Number:149354-10-9
Molecular formula:C15H21NO3
Molecular Weight:263.33

2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-OL

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24424-99-5 Synthesis

24424-99-5
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7-hydroxy-4,5-dihydro-1H-benzo[d]azepine-3(2H)-carboxylic acid

149354-10-9
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Yield:149354-10-9 93%

Reaction Conditions:

with triethylamine in tetrahydrofuran;water at 20; for 18 h;Acylation;

References:

Austin, Nigel E.;Avenell, Kim Y.;Boyfield, Izzy;Branch, Clive L.;Hadley, Michael S.;Jeffrey, Phillip;Johnson, Christopher N.;Macdonald, Gregor J.;Nash, David J.;Riley, Graham J.;Smith, Alexander B.;Stemp, Geoffrey;Thewlis, Kevin M.;Vong, Antonio K. K.;Wood, Martyn [Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,# 22,p. 2553 - 2555]

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