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Carbamic acid, [(1R)-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester (9CI) synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran
2: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr

References:

Burk, Mark J.;Johnson, Nicholas B.;Lee, Jeffrey R. [Tetrahedron Letters,1999,vol. 40,# 36,p. 6685 - 6688]