ChemicalBook CAS DataBase List N-BOC-(S)-2-AMINO-1-BUTANOL, 96%

N-BOC-(S)-2-AMINO-1-BUTANOL, 96% synthesis

7synthesis methods

Product Name:N-BOC-(S)-2-AMINO-1-BUTANOL, 96%
CAS Number:150736-72-4
Molecular formula:C9H19NO3
Molecular Weight:189.25

5856-62-2
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24424-99-5 Synthesis

24424-99-5
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150736-72-4
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Yield:150736-72-4 100%

Reaction Conditions:

in dichloromethane at 0;

Steps:

45.A

Example 45; 2-cyclohexyl-(J S)-(morpholine-4-carbonyl)ethvl (IS(at)S-cyclopropyl-[1,2,4]oxadiazole-3- carbonyl)-propyl carbamate; [0072] Step A; Intermediate 2 is synthesized from commercially available (S)-2- amino-butan-1-ol (1): 1 (10.0 g, 112 mmol, 1.0 eq) is dissolved in 500 mL of dry DCM. Boc anhydride (26.93 g, 123.4 mmol, 1.1 eq) is dissolved in 200 mL of dry DCM and added to 1 at 0°C via addition funnel over a period of 1 hour. After the reaction mixture is stirred overnight, it is worked up with 25% NH40H. The organic layer is separated and dried over MgS04. Evaporation of the solvent provides pure 2 in quantitative yield.

References:

WO2005/107464,2005,A2 Location in patent:Page/Page column 36

5856-62-2
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$6.00/5g