ChemicalBook CAS DataBase List 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI)

1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI) synthesis

11synthesis methods

Product Name:1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI)
CAS Number:152673-32-0
Molecular formula:C10H20N2O2
Molecular Weight:200.28

114676-69-6 Synthesis

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

114676-69-6
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1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI)

152673-32-0
37 suppliers
$450.00/250mg

Yield:-

Steps:

Multi-step reaction with 8 steps
1: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature
2: 93 percent / lithium borohydride / tetrahydrofuran / 16 h
3: 94 percent / triethylamine / CH₂Cl₂ / 15 h
4: lithium triethylborohydride / tetrahydrofuran / 2 h
5: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h
6: 16.1 g / triethylamine / CH₂Cl₂ / 14 h
7: 43 percent / tetra-n-butylammonium azide / acetonitrile / 3 h / 65 °C
8: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr

References:

Rosen, Terry;Chu, Daniel T. W.;Lico, Isabella M.;Fernandes, Prabhavathi B.;Marsh, Kennan;et al. [Journal of Medicinal Chemistry,1988,vol. 31,# 8,p. 1598 - 1611]

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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152673-32-0
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References

24424-99-5 Synthesis

24424-99-5
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152673-32-0
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References

D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-

114676-59-4
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$6.00/250mg

152673-32-0
37 suppliers
$450.00/250mg

References

1000210-73-0
0 suppliers
inquiry

152673-32-0
37 suppliers
$450.00/250mg

References

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