![](/CAS/GIF/114676-69-6.gif)
(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate synthesis
- Product Name:(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- CAS Number:114676-69-6
- Molecular formula:C11H19NO5
- Molecular Weight:245.27
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-](/CAS/GIF/114676-59-4.gif)
114676-59-4
104 suppliers
$6.00/250mg
![(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate](/CAS/GIF/114676-69-6.gif)
114676-69-6
177 suppliers
$6.00/1g
Yield:114676-69-6 100%
Reaction Conditions:
with dmap;triethylamine in water;acetone;
Steps:
1.4.2
[0347] To a solution of (2R,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride (4.4 g, 24.67 mmol) in Acetone and water (3:2, 30 mL) were added Et3N (6.8 mL , 49.28 mmol), DMAP (150 mg, 1.2 mmol). Then (Boc)20 (8.0 mL, 34.54 mmol) was added slowly and the reaction was stirred overnight. All the acetone was removed and diluted with EtOAc and washed with 0.5 N HC1, water, brine, dried and concentrated to yield 6.0 g of (2R,4R)-1- tert-butyl 2-methyl 4-hydroxypyrrolidine-l,2-dicarboxylate (quantitative).
References:
WO2011/130383,2011,A1 Location in patent:Page/Page column 104
![(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid](/CAS/GIF/135042-12-5.gif)
135042-12-5
186 suppliers
$6.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
342 suppliers
$15.00/10g
![(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate](/CAS/GIF/114676-69-6.gif)
114676-69-6
177 suppliers
$6.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![cis-4-Hydroxy-D-proline](/CAS/GIF/2584-71-6.gif)
2584-71-6
323 suppliers
$6.00/1g
![(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate](/CAS/GIF/114676-69-6.gif)
114676-69-6
177 suppliers
$6.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![CIS-4-HYDROXY-D-PROLINE METHYL ESTER](/CAS/GIF/114676-47-0.gif)
114676-47-0
45 suppliers
$95.00/250mg
![(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate](/CAS/GIF/114676-69-6.gif)
114676-69-6
177 suppliers
$6.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$9.00/25ml
![(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid](/CAS/GIF/135042-12-5.gif)
135042-12-5
186 suppliers
$6.00/1g
![(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate](/CAS/GIF/114676-69-6.gif)
114676-69-6
177 suppliers
$6.00/1g