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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate structure

CAS No.: 114676-69-6

Chemical Name:: (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Synonyms: (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-cis-4-Hydroxy-D-proline methyl ester;1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-Cis-D-Hyp-OMe;cis-Boc-d-Hyp-Ome;N-Boc-cis-D-Hyp-Ome;(2R,4R)-1-Boc-4-hydroxypyrroL;CIS-1-BOC-4-HYDROXY-D-PROLINATE;(Tert-Butoxy)Carbonyl D-cis-Hyp-OMe;Methyl cis-Boc-4-hydroxy-D-prolinate

CBNumber:: CB51118684

Molecular Formula:: C11H19NO5

Molecular Weight:: 245.27

MDL Number:: MFCD00797548

MOL File:: 114676-69-6.mol

Last updated:2024-11-01 18:09:03

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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Properties

Melting point	76 °C
Boiling point	335.2±42.0 °C(Predicted)
alpha	63° (C=1,EtOH)
Density	1.216±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
form	Powder
pka	14.27±0.40(Predicted)
color	White

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2933998090

NFPA 704

	1
2		0

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5857	N-(tert-Butoxycarbonyl)-cis-4-hydroxy-D-proline Methyl Ester >97.0%(GC)	114676-69-6	1g	$19	2024-03-01	Buy
TCI Chemical	B5857	N-(tert-Butoxycarbonyl)-cis-4-hydroxy-D-proline Methyl Ester >97.0%(GC)	114676-69-6	5g	$43	2024-03-01	Buy
Alfa Aesar	H63136	N-Boc-cis-4-hydroxy-D-proline methyl ester, 95%	114676-69-6	1g	$62.65	2024-03-01	Buy
Alfa Aesar	H63136	N-Boc-cis-4-hydroxy-D-proline methyl ester, 95%	114676-69-6	5g	$243.65	2024-03-01	Buy
Alfa Aesar	H63136	N-Boc-cis-4-hydroxy-D-proline methyl ester, 95%	114676-69-6	250mg	$21.4	2021-12-16	Buy

Product number	Packaging	Price	Buy
B5857	1g	$19	Buy
B5857	5g	$43	Buy
H63136	1g	$62.65	Buy
H63136	5g	$243.65	Buy
H63136	250mg	$21.4	Buy

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Chemical Properties,Uses,Production

Uses

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (N-Boc-cis-4-hydroxy-D-proline methyl ester) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate synthesis

Synthesis of (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate from Di-tert-butyl dicarbonate and D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Suppliers

Global( 198)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PRISUN PHARMATECH CO.,LTD	+86-021-54326183-8001 +8618917565227	prisun@prisunpharma.com	China	215	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18644	58
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	19943	58
Chengdu Pukang Biotechnology Co., Ltd	028-82550498	export@pu-kang.com	CHINA	210	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2158	58

Supplier	Advantage
PRISUN PHARMATECH CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Shanghai Time Chemicals CO., Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Chengdu Pukang Biotechnology Co., Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-01	N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester 114676-69-6	US $0.00 / kg	20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
	2019-12-20	METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE 114676-69-6	US $1.00 / ASSAYS	1ASSAYS	97-99%	1000KGS	Career Henan Chemical Co

N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester
114676-69-6
US $0.00 / kg
99%
Qingdao RENAS Polymer Material Co., Ltd.

METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE
114676-69-6
US $1.00 / ASSAYS
97-99%
Career Henan Chemical Co

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Spectrum

METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE (114676-69-6)¹HNMR

114676-69-6((2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate )Related Search:

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(S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate BOC-N-methyl-D-alanine

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(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicacid 1-(1,1-dimethylethyl) 2-methyl ester (2R,4R)-1-tert-butyl 2-Methyl 4-hydroxypyrrolidine-1,2-dicarboxy (2R,4R)-1-tert-butyl 2-Methyl 4-hydro×ypyrrolidine-1,2-dicarbo×ylate Boc-Cis-D-Hyp-OMe Methy cis-1-Boc-4-hydroxy-D-prolinate Methyl cis-Boc-4-hydroxy-D-prolinate 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)- N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester Methyl cis-1-Boc-4-hydroxy-D-prolinate N-Boc-cis-4-hydroxy-D-proline methyl ester Methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate (Tert-Butoxy)Carbonyl D-cis-Hyp-OMe CIS-1-BOC-4-HYDROXY-D-PROLINATE (2R,4R)-N-Boc-4-hydroxyproline methyl ester (2R,4R)-N-Boc-cis-4-hydroxy-D-proline methyl ester N-Boc-cis-D-Hyp-Ome (2R,4R)-1-Boc-4-hydroxypyrroL N-Boc-cis-4-hydroxy-D-prolinemethylester,95% (2R,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE USP/EP/BP O1-tert-Butyl O2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate cis-Boc-d-Hyp-Ome 1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Boc-cis-4-Hydroxy-D-proline methyl ester 1-(1,1-Dimethylethyl) 2-methyl (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate BOC cis D hydroxyproline methyl ester 114676-69-6