ChemicalBook CAS DataBase List (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol

(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol synthesis

4synthesis methods

Product Name:(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol
CAS Number:153004-31-0
Molecular formula:C32H47F5O2S
Molecular Weight:590.77

S-Deoxo-3,17β-bis-(O-tetrahydro-2H-pyran-2-yl)-6-oxo-fulvestrant

862700-70-7
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(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol

153004-31-0
108 suppliers
$498.06/5MG

Yield:153004-31-0 81%

Reaction Conditions:

with triethylsilane;boron trifluoride diethyl etherate in dichloromethane at 0; for 14 h;

Steps:

Synthesis of Compound 7; To a solution of compound 6 (8.8g, 11.38 mmol) in dichloromethane (440 mL) was added Et₃SiH (88 mL). The reaction was cooled to 0 ⁰C. BF₃ Et₂O (176 mL) was added dropwise. After the addition was complete (-14 h). The mixture was extracted with ethyl acetate (250 ml, 200 ml and 150 ml). The combined extract was washed with saturated brine(200 ml x 2) and dried over Na₂SO₄. Solvent was evaporated to give a crude product. The crude product was purified by a short silica gel chromatography using ethyl acetate/Hexane 1:1 as eluents to give pure compound 7 (5.45 g, 81%).

References:

WO2009/39700,2009,A1 Location in patent:Page/Page column 6-7

129453-61-8 Synthesis