2-Thiophenecarboxylic acid, 3-amino-4-cyclopropyl-, 1,1-dimethylethyl ester synthesis
- Product Name:2-Thiophenecarboxylic acid, 3-amino-4-cyclopropyl-, 1,1-dimethylethyl ester
- CAS Number:1603055-06-6
- Molecular formula:C12H17NO2S
- Molecular Weight:239.33
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Yield:1603055-06-6 65%
Reaction Conditions:
Stage #1: 2-cyclopropylacetonitrilewith lithium diisopropyl amide in tetrahydrofuran;hexane at -40;Inert atmosphere;
Stage #2: ethyl thioformate in tetrahydrofuran;hexane at -40;Inert atmosphere;
Stage #3: tert-Butyl chloroacetate in tetrahydrofuran;hexane at -40; for 0.5 h;Inert atmosphere;
References:
Zhang, Haiming;Bednarz, Mark S.;Lim, Ngiap-Kie;Hernandez, Gonzalo;Wu, Wenxue [Organic Letters,2014,vol. 16,# 9,p. 2522 - 2525] Location in patent:supporting information