ChemicalBook CAS DataBase List 2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate

2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate synthesis

8synthesis methods

Product Name:2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate
CAS Number:1609373-98-9
Molecular formula:C13H8F3NO4S
Molecular Weight:331.27

358-23-6 Synthesis

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1609373-97-8 Synthesis

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2-Methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate

1609373-98-9
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Yield:1609373-98-9 80%

Reaction Conditions:

with pyridine in dichloromethane at 0;

Steps:

Preparation of 2-methylbenzofuro[2,3-b]pyridin-8-yl trifluoromethanesulfonate

Into a suspension of 2-methylbenzofuro[2,3-b]pyridin-8-ol (6.7 g, 33.6 mmol) in dichloromethane (300 ml) wasadded dropwise a solution of trifluoromethanesulfonic anhydride (8.47 ml, 50.5 mmol) in dichloromethane (30 ml) at 0°C. After stirring overnight, the reaction was quenched with saturated sodium bicarbonate. The organic phase wasisolated, washed with brine and dried over sodium sulfate. Upon evaporation off the solvent, the crude product waspurified by column chromatography on silica gel with dichloromethane as eluent to obtain 8.95 g (80%) of desired productas a pale yellow solid.

References:

EP2730583,2014,A1 Location in patent:Paragraph 0155; 0156

1609373-96-7 Synthesis