ChemicalBook CAS DataBase List 18-aminooctadecanoic acid

18-aminooctadecanoic acid synthesis

6synthesis methods

Product Name:18-aminooctadecanoic acid
CAS Number:17437-24-0
Molecular formula:C18H37NO2
Molecular Weight:299.49

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17437-24-0
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Yield:17437-24-0 100%

Reaction Conditions:

with hydrogen;acetic acid;10% Pd(OH)2/C at 60;

Steps:

23

18-Aminooctadecanoic acid NH2 (CH2)17CO2H Intermediate 22 (13g) under an atmosphere of hydrogen was heated at 60°C overnight in glacial acetic acid with Pearlman's catalyst (10% w/w). The reaction was filtered hot through glass fibre & evaporated to dryness. The product was crystallised from acetic acid/ ether (8.2g, 100%). The product was subjected to high vacuum to remove traces of acetic acid. Mp 162-163°C. C24H49N02.0.25H20 requires C: 71.12%, H: 12.43%, N: 4.61%. Found: C: 71.20%, H: 12.35%, N: 4.49%. m/z (ES+, 70V) 300 (MH+). No.H (CD3C02D) 3.06 (2H, t), 2.38 (2H, t), 1.63-1.73 (4H, m), 1.33 (26H, m).

References:

WO2005/117984,2005,A2 Location in patent:Page/Page column 31-32