![](/CAS/GIF/46006-36-4.gif)
1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID
- CAS Number:46006-36-4
- Molecular formula:C8H6N2O2
- Molecular Weight:162.15
![Triethyl orthoformate](/CAS/GIF/122-51-0.gif)
122-51-0
485 suppliers
$10.00/5ml
![2,3-Diaminobenzoic acid](/CAS/GIF/603-81-6.gif)
603-81-6
183 suppliers
$7.00/250mg
![1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/46006-36-4.gif)
46006-36-4
143 suppliers
$19.00/250mg
Yield: 98%
Reaction Conditions:
at 130;
Steps:
5.1.92.A
A. lH-Benzo[d]imidazole-4-carboxyIic acid.; 2,3-Diaminobenzoic acid (1.0 g, 6.57 mmol) was suspended in triethylorthoformate (20 mL) and heated to 130 0C overnight. Diethyl ether (100 mL) was then added and the resulting precipitate filtered to give a white solid (1.04 g, 6.41 mmol, 98%). 1H NMR (400 MHz, DMSO-rf6) δ 8.22 (s, IH), 7.91 (dd, J = S.0, 1.2, IH), 7.82 (dd, J = 8.0, 1.2, IH), 7.29 (dd, J = 8.0, 7.6, IH); MS (ESI) m/z 163.0 [M+ 1]+.
References:
SIGNAL PHARMACEUTICALS, LLC WO2008/51494, 2008, A1 Location in patent:Page/Page column 132
![Formic acid](/CAS/GIF/64-18-6.gif)
64-18-6
1061 suppliers
$22.12/250ML
![2,3-Diaminobenzoic acid](/CAS/GIF/603-81-6.gif)
603-81-6
183 suppliers
$7.00/250mg
![1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/46006-36-4.gif)
46006-36-4
143 suppliers
$19.00/250mg
![Formic acid](/CAS/GIF/64-18-6.gif)
64-18-6
1061 suppliers
$22.12/250ML
![1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/46006-36-4.gif)
46006-36-4
143 suppliers
$19.00/250mg
![2,3-Diaminobenzoic acid](/CAS/GIF/603-81-6.gif)
603-81-6
183 suppliers
$7.00/250mg
![4-Benzoxazolecarboxylic acid](/CAS/GIF/208772-23-0.gif)
208772-23-0
57 suppliers
$45.00/10mg
![1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/46006-36-4.gif)
46006-36-4
143 suppliers
$19.00/250mg
![2-Amino-3-nitrobenzoic acid](/CAS/GIF/606-18-8.gif)
606-18-8
295 suppliers
$9.00/1g
![1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/46006-36-4.gif)
46006-36-4
143 suppliers
$19.00/250mg