ChemicalBook CAS DataBase List 2,2'-DICHLORO-[4,4']-BIPYRIDINE

2,2'-DICHLORO-[4,4']-BIPYRIDINE synthesis

9synthesis methods

Product Name:2,2'-DICHLORO-[4,4']-BIPYRIDINE
CAS Number:53344-74-4
Molecular formula:C10H6Cl2N2
Molecular Weight:225.07

24573-15-7
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$279.23/1gm:

53344-74-4
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$86.90/100mg

Yield: 79%

Reaction Conditions:

with trichlorophosphate for 3 h;Reflux;Inert atmosphere;

Steps:

2.1.2. Synthesis of bipyridine derivatives
Synthesis of 2,20-dichloro-4,40-bipyridine (B). Phosphorousoxychloride POCl3 (18.65 ml, 0.2 mol) was added to 4,40-bipyridine-N,N’-dioxide (A) (1.88 g, 10.0 mmol) and the solution was refluxedfor 3 hours. The reaction mixture was poured onto crushed ice andthen neutralized with saturated solution of K2CO3 to give a brightgreen precipitate. The crude product wasfiltered off, washed withacetone and dried under vacuum (1.78 g, 79% yield). The structureof the product was confirmed by 1H NMR, 13C NMR and ESI-MSanalysis. Without further purification it was used to obtain (1).

References:

Zassowski, Pawel;Golba, Sylwia;Skorka, Lukasz;Szafraniec-Gorol, Grazyna;Matussek, Marek;Zych, Dawid;Danikiewicz, Witold;Krompiec, Stanislaw;Lapkowski, Mieczyslaw;Slodek, Aneta;Domagala, Wojciech [Electrochimica Acta,2017,vol. 231,p. 437 - 452]