2-(2-METHOXYPHENOXY)ANILINE synthesis

5synthesis methods

Product Name:2-(2-METHOXYPHENOXY)ANILINE
CAS Number:22751-09-3
Molecular formula:C13H13NO2
Molecular Weight:215.25

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Yield:-

Reaction Conditions:

with hydrogenchloride;iron in ethanol at 80; for 2.16667 h;

Steps:

2.11 4.2.1.2 Synthesis of 2-amine-aryloxybenzenes (4a-4i)

General procedure: To a slurry mixture of iron powder (150 mmol) and compound 3 (50 mmol) in absolute alcohol (40 mL), a solution of concentrated HCl (5 mL) in absolute alcohol (10 mL) was added dropwise in 10 min at 80°C. Then the mixture was stirred for another 2h at 80°C. Finally, the reaction mixture was alkalized by NaOH solution and filtered. The solvent in the collected filtrate was removed in a vacuum to give the crude product. The crude product was purified using a silica gel chromatography column to give compounds 4a-4i in yields of 38-51%.

References:

Wen, Fang;Jin, Hong;Tao, Ke;Hou, Taiping [European Journal of Medicinal Chemistry,2016,vol. 120,p. 244 - 251]

90-05-1 Synthesis