ChemicalBook CAS DataBase List 2-(2-THIENYL)QUINOXALINE

2-(2-THIENYL)QUINOXALINE synthesis

12synthesis methods

Product Name:2-(2-THIENYL)QUINOXALINE
CAS Number:40353-41-1
Molecular formula:C12H8N2S
Molecular Weight:212.27

1448-87-9 Synthesis

1448-87-9
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1158984-92-9
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40353-41-1
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Yield:40353-41-1 97%

Reaction Conditions:

Stage #1: 2-chloroquinoxaline;2-thiopheneboronic acid MIDA esterwith dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane;palladium diacetate in 1,4-dioxane at 23; for 0.166667 h;Inert atmosphere;
Stage #2: with potassium phosphate;water in 1,4-dioxane at 23 - 60; for 6.5 h;Inert atmosphere;

References:

Knapp, David M.;Gillis, Eric P.;Burke, Martin D. [Journal of the American Chemical Society,2009,vol. 131,p. 6961 - 6963] Location in patent:supporting information; experimental part