![](/CAS/GIF/480-63-7.gif)
2,4,6-Trimethylbenzoic acid synthesis
- Product Name:2,4,6-Trimethylbenzoic acid
- CAS Number:480-63-7
- Molecular formula:C10H12O2
- Molecular Weight:164.2
![Mesitaldehyde](/CAS/GIF/487-68-3.gif)
487-68-3
336 suppliers
$6.00/5g
![2,4,6-Trimethylbenzoic acid](/CAS/GIF/480-63-7.gif)
480-63-7
323 suppliers
$6.00/5g
Yield:480-63-7 90%
Reaction Conditions:
with tris[2-(4,6-difluorophenyl)pyridinato-C2,N]-iridium(III);oxygen in acetonitrile at 20;Irradiation;Sealed tube;Green chemistry;chemoselective reaction;
Steps:
Synthesis of carboxylic acids
General procedure: An oven-dried resealable test tube equipped with a magnetic stir bar was charged withaldehyde (1.0 mmol), Ir(dFppy)3 (0.005-0.01 mmol), and MeCN (4.0 mL, 0.25 M). Oxygen wasthen bubbled through the reaction mixture and sealed with a silicone septa screw-cap. A balloonfilled with oxygen was attached to the tube, and the test tube was placed under blue LEDs atroom temperature. The reaction was allowed to proceed for 3-12 h, and reaction progress waschecked by TLC. The solvent was removed under vacuum, and the corresponding carboxylic acidwas purified by flash silica gel chromatography.
References:
Iqbal, Naeem;Choi, Sungkyu;You, Youngmin;Cho, Eun Jin [Tetrahedron Letters,2013,vol. 54,# 46,p. 6222 - 6225] Location in patent:supporting information
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
122 suppliers
$175.00/23402
![Mesitylene](/CAS/GIF/108-67-8.gif)
108-67-8
363 suppliers
$5.00/5 g
![2,4,6-Trimethylbenzoic acid](/CAS/GIF/480-63-7.gif)
480-63-7
323 suppliers
$6.00/5g
![2,4,6-Trimethyliodobenzene](/CAS/GIF/4028-63-1.gif)
4028-63-1
170 suppliers
$9.00/1g
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
122 suppliers
$175.00/23402
![2,4,6-Trimethylbenzoic acid](/CAS/GIF/480-63-7.gif)
480-63-7
323 suppliers
$6.00/5g
![2,4,6-Trimethylbenzyl alcohol](/CAS/GIF/4170-90-5.gif)
4170-90-5
119 suppliers
$11.00/250mg
![2,4,6-Trimethylbenzoic acid](/CAS/GIF/480-63-7.gif)
480-63-7
323 suppliers
$6.00/5g
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
122 suppliers
$175.00/23402
![SodiuM 2,4,6-triMethylbenzenesulfinate](/CAS/20150408/GIF/50827-54-8.gif)
50827-54-8
17 suppliers
$220.00/2.5g
![2,4,6-Trimethylbenzoic acid](/CAS/GIF/480-63-7.gif)
480-63-7
323 suppliers
$6.00/5g