2-(4-CHLOROPHENYL)-2-METHYLOXIRANE synthesis

7synthesis methods

Product Name:2-(4-CHLOROPHENYL)-2-METHYLOXIRANE
CAS Number:1669-70-1
Molecular formula:C9H9ClO
Molecular Weight:168.62

2181-42-2 Synthesis

2181-42-2
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$6.00/5g

99-91-2 Synthesis

99-91-2
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$10.00/25g

1669-70-1
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Yield:1669-70-1 96%

Reaction Conditions:

Stage #1: trimethylsulphonium iodidewith sodium hydride in tetrahydrofuran;dimethyl sulfoxide;mineral oil at 20; for 0.5 h;Schlenk technique;Inert atmosphere;
Stage #2: para-chloroacetophenone in tetrahydrofuran;dimethyl sulfoxide;mineral oil at 0 - 20;Inert atmosphere;Schlenk technique;

References:

Vyas, Devendra J.;Larionov, Evgeny;Besnard, Celine;Guenee, Laure;Mazet, Clement [Journal of the American Chemical Society,2013,vol. 135,# 16,p. 6177 - 6183] Location in patent:supporting information

1774-47-6 Synthesis