ChemicalBook CAS DataBase List 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE

2,4-DICHLOROFURO[3,2-D]PYRIMIDINE synthesis

5synthesis methods

Product Name:2,4-DICHLOROFURO[3,2-D]PYRIMIDINE
CAS Number:956034-07-4
Molecular formula:C6H2Cl2N2O
Molecular Weight:189

956034-06-3
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956034-07-4
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Yield:956034-07-4 87%

Reaction Conditions:

with N,N-dimethyl-aniline;trichlorophosphate at 130; for 2 h;

Steps:

10; vii
To a mixture of lH-furo[3,2-d]pyrimidine-2,4-dione (3.0 g, 0.020 mol) in NJf- dimethylaniline (2.0 mL, 0.016 mol) was added phosphorous oxychloride (18.0 mL, 0.193 mol) and the resulting mixture heated at 130 °C for 2 h. The resulting black solution was cooled to RT, then carefully quenched with crushed ice and H₂O, then extracted with EtOAc.The organic layer was isolated, dried (MgSO₄) and concentrated in vacuo to give the title compound as a tan solid (3.26 g, 87 %). ¹H NMR (400 MHz, CDCl₃): δ 7.02 (d, J = 2.2 Hz, 1 H) and 8.08 (d, J = 2.2 Hz, 1 H).

References:

F.HOFFMANN-LA ROCHE AG WO2008/152394, 2008, A1 Location in patent:Page/Page column 25; 35

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956034-06-3
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956034-07-4
141 suppliers
$50.00/100mg

References

956034-03-0 Synthesis