ChemicalBook CAS DataBase List 2,5-Piperidinedione

2,5-Piperidinedione synthesis

7synthesis methods

Product Name:2,5-Piperidinedione
CAS Number:52065-78-8
Molecular formula:C5H7NO2
Molecular Weight:113.11

19365-07-2
112 suppliers
$65.00/250mg

52065-78-8
90 suppliers
$65.00/10mg

Yield:52065-78-8 37.9%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 20;Inert atmosphere;

Steps:

1.6 Example 1
(6) at room temperature, 6 g of Compound 6 was dispersed in DCM, The Dess-Martinin oxidizer (Dess-martin) was added to the system, Under nitrogen protection, Room temperature reaction overnight.After the reaction is complete,System directly filter,The filter cake was rinsed with 50 mL of methanol,Filtrate pump concentration,Mixed with 30g pillars,The more clean part of the concentration,Precipitation of solids,After addition of 20 mL DCM,The cake was dried to give 1 g of the desired product.,

References:

Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.;Yao Qingjia;Wu Simin;Xu Yangjun CN106748972, 2017, A Location in patent:Paragraph 0022; 0023; 0029; 0030; 0031

FullText

5154-01-8 Synthesis