![](/CAS/GIF/5600-21-5.gif)
2-Amino-4-chloro-6-methylpyrimidine synthesis
- Product Name:2-Amino-4-chloro-6-methylpyrimidine
- CAS Number:5600-21-5
- Molecular formula:C5H6ClN3
- Molecular Weight:143.57
![2-Amino-6-methyl-4-pyrimidinol](/CAS/GIF/3977-29-5.gif)
3977-29-5
252 suppliers
$6.00/10g
![2-Amino-4-chloro-6-methylpyrimidine](/CAS/GIF/5600-21-5.gif)
5600-21-5
318 suppliers
$18.00/25g
Yield:5600-21-5 54%
Reaction Conditions:
with trichlorophosphateReflux;
Steps:
2-Amino-4-chloro-6-methylpyrimidine (III
Amixture of 6 g of isocytosine IV and 35 mL of freshlydistilled phosphorus oxychloride was refluxed till themixture became homogeneous, then the excess of thechlorinating agent was removed in a vacuum. Forcooling, the residue was mixed with ice and treatedwith 25% aqueous ammonia to 8. The formedsuspension was filtered, the precipitate was washedwith water, crystallized from 50% ethanol, and dried toa constant mass. Yield 3.7 g (54%), mp 188° (mp182-183° [7]), Rf 0.79 (D). Found, %: 41.74;4.05; N 29.35. C5H6ClN3. Calculated, %: 41.83;4.21; N 29.27.
References:
Erkin, A. V.;Krutikov, V. I.;Gurzhii, V. V. [Russian Journal of General Chemistry,2015,vol. 85,# 1,p. 79 - 87][Zh. Obshch. Khim.,2015,vol. 85,# 1,p. 79 - 87,9][Zhurnal Obshchei Khimii,2015,vol. 85,# 1,p. 79 - 87,9]
![2-Amino-6-methyl-4-pyrimidinol](/CAS/GIF/3977-29-5.gif)
3977-29-5
252 suppliers
$6.00/10g
![2-Amino-4-chloro-6-methylpyrimidine](/CAS/GIF/5600-21-5.gif)
5600-21-5
318 suppliers
$18.00/25g
![2,4-Dichloro-6-methylpyrimidine](/CAS/20180808/GIF/5424-21-5.gif)
5424-21-5
316 suppliers
$10.00/5g
![2-Amino-4-chloro-6-methylpyrimidine](/CAS/GIF/5600-21-5.gif)
5600-21-5
318 suppliers
$18.00/25g
![2-Chloro-6-methylpyrimidin-4-ylamine](/CAS/GIF/14394-60-6.gif)
14394-60-6
139 suppliers
$45.00/100mg
![4-Chloro-2-ethylsulfanyl-6-methyl-pyrimidine](/StructureFile/ChemBookStructure22/GIF/CB6948526.gif)
22727-18-0
14 suppliers
$144.00/250mg
![2-Amino-4-chloro-6-methylpyrimidine](/CAS/GIF/5600-21-5.gif)
5600-21-5
318 suppliers
$18.00/25g
![2,4-Dichloro-6-methylpyrimidine](/CAS/20180808/GIF/5424-21-5.gif)
5424-21-5
316 suppliers
$10.00/5g
![2-Amino-4-chloro-6-methylpyrimidine](/CAS/GIF/5600-21-5.gif)
5600-21-5
318 suppliers
$18.00/25g