![](/CAS/GIF/14394-70-8.gif)
4-Amino-2-chloro-5-methylpyrimidine synthesis
- Product Name:4-Amino-2-chloro-5-methylpyrimidine
- CAS Number:14394-70-8
- Molecular formula:C5H6ClN3
- Molecular Weight:143.57
![2,4-Dichloro-5-methylpyrimidine](/CAS/GIF/1780-31-0.gif)
1780-31-0
351 suppliers
$10.00/5g
![2-Pyrimidinamine, 4-chloro-5-methyl- (9CI)](/CAS/GIF/20090-58-8.gif)
20090-58-8
106 suppliers
$75.00/250mg
![4-Amino-2-chloro-5-methylpyrimidine](/CAS/GIF/14394-70-8.gif)
14394-70-8
136 suppliers
$70.00/2 g
Yield:-
Reaction Conditions:
with ammonia;N-ethyl-N,N-diisopropylamine in 1,4-dioxane;water at 100; for 0.25 h;Irradiation;CEM discover microwave at 100W;
Steps:
20.a; 21.a a) 2-Chloro-5-methyl-4-pyrimidinamine & 4-chloro-5-methyl-2-pyrimidinamine
2,4-dichloro-5-methylpyrimidine (2.6g), Hunigs base (2. 8ML) and aqueous ammonia (4ml) in dioxane (4ml) were irradiated in a CEM discover microwave at 100 C/100W for 15MIN. The resultant mixture was shaken between isohexane and sat. aq. sodium hydrogen carbonate. The insoluble white solid was filtered off and dried in vacuo to give a mixture of the sub-title compounds (2g). 2-chloro-5-methyl-4-pyrimidinamine: Major (85%) LH NMR 6 (DMSO) 7.82 (s, LH), 7.21 (s, 2H), 1.94 (s, 3H) 4-CHLORO-5-METHYL-2-PYRIMIDINAMINE : Minor (15%) H NMR 8 (DMSO) 8.13 (s, lH), 6.83 (s, 2H), 2.07 (s, 3H)
References:
ASTRAZENECA AB WO2004/74278, 2004, A1 Location in patent:Page 31-33