2-Amino-5-bromo-6-methylpyridine synthesis
- Product Name:2-Amino-5-bromo-6-methylpyridine
- CAS Number:42753-71-9
- Molecular formula:C6H7BrN2
- Molecular Weight:187.04
3430-17-9
447 suppliers
$4.00/5g
42753-71-9
379 suppliers
$6.00/5g
Yield:42753-71-9 90.1%
Reaction Conditions:
with sodium amide in 5,5-dimethyl-1,3-cyclohexadiene at 118 - 120; for 1 h;Inert atmosphere;Time;Concentration;
Steps:
2 Example 2
Example 2
To the reaction tank was charged 650g of xylene as a solvent, heated up to 115 ~ 120 deg. C heated under reflux until complete removal of the water; under nitrogen, the solvent was cooled to 70 deg. C, sodium amide was added 22g, and then the solution was heated to 118 to 120 deg. C, was added dropwise under reflux 102g of 2-bromo-3-methylpyridine, the addition was complete, the reaction maintaining the temperature at reflux 1H; After the reaction, the reaction solution was cooled to 45 deg. C, and then poured into ice water, separation of the upper solvent layer; xylene was concentrated at atmospheric pressure, the remaining 220g, stirring cooling to 10 ~ 15 deg. C, crystallization give the desired product 2- methyl-6-amino-5-bromopyridine 100g, content 99.3%, yield 90.1%.
References:
CN105348181,2016,A Location in patent:Paragraph 0023; 0024; 0025
1824-81-3
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42753-71-9
379 suppliers
$6.00/5g
1824-81-3
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$8.00/25g
42753-71-9
379 suppliers
$6.00/5g
91872-10-5
214 suppliers
$5.00/1g
1824-81-3
476 suppliers
$8.00/25g
42753-71-9
379 suppliers
$6.00/5g
91872-10-5
214 suppliers
$5.00/1g
126325-46-0
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$10.00/250mg