2-Amino-5-chloro-3-fluoropyridine synthesis
- Product Name:2-Amino-5-chloro-3-fluoropyridine
- CAS Number:246847-98-3
- Molecular formula:C5H4ClFN2
- Molecular Weight:146.55
89402-43-7
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246847-98-3
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Yield: 85.94%
Reaction Conditions:
with ammonia at 120; for 24 h;Autoclave;Temperature;
Steps:
6.A A.2-amino-3-fluoro-5-chloropyridine
5-chloro-2,3-difluoro-pyridine (100g, 0.669mol) and ammonia (1.125L, 8.025mol) added to the autoclave.After the reaction 120 sealed 24h, the reaction was complete, the cooling pale yellow solid precipitation, filtration, the filter cake was washed with water, and the filtrate was extracted with ethyl acetate, and the combined organic layer was dried over anhydrous sodium sulfate, the organic phase was distilled off under reduced pressure, with beating a small amount of petroleum ether, filtration, and precipitation cake cake obtained will be collected at the same time to give the compound 2-amino-3-fluoro-5-chloropyridine 84.22g, yield 85.94%.
References:
Guizhou University;Zhao, Chunshen;Chai, Huifang;Liu, LI;Huang, Zhuyan;Le, Yi CN105669539, 2016, A Location in patent:Paragraph 0058; 0059; 0060
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246847-98-3
115 suppliers
$6.00/1g