![](/CAS/GIF/3158-98-3.gif)
2-amino-5-chloro-alpha-methylbenzhydryl alcohol synthesis
- Product Name:2-amino-5-chloro-alpha-methylbenzhydryl alcohol
- CAS Number:3158-98-3
- Molecular formula:C14H14ClNO
- Molecular Weight:247.72
![METHYLMAGNESIUM IODIDE](/CAS/GIF/917-64-6.gif)
917-64-6
146 suppliers
$45.00/10ml
![2-Amino-5-chlorobenzophenone](/CAS/GIF/719-59-5.gif)
719-59-5
521 suppliers
$10.00/5g
![2-amino-5-chloro-alpha-methylbenzhydryl alcohol](/CAS/GIF/3158-98-3.gif)
3158-98-3
21 suppliers
$112.00/100mg
Yield:3158-98-3 530 mg
Reaction Conditions:
in diethyl ether at 0 - 20; for 5 h;Inert atmosphere;
Steps:
1 00151] Synthesis of l-(2-amino-5-chlorophenyl)-1-phenyethan-1-ol.
To 2-amino-5- chlorobenzophenone (2.34 mmols, 541 mgs) in diethyl ether (lOmL ) under nitrogen atmosphere at 0 °C was added dropwise methylmagnesium iodide (3.12 mL, 3.0M in diethyl ether). The reaction mixture was stirred and left to warm to room temperature. After 5 hours, the mixture was cooled to 0 °C and ice chips were carefully added followed by cold water. Brine was added to separate the phases. The ether layer was separated. The aqueous layer was extracted with an equal amount of ether. The combined ether layers were dried over magnesium sulfate, filtered and concentrated under vacuum to yield the tertiary alcohol (2.14 mmols, 530 mgs). MS: (M+H) 248.
References:
WO2016/154039,2016,A1 Location in patent:Paragraph 00151
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
264 suppliers
$12.00/10ml
![2-Amino-5-chlorobenzophenone](/CAS/GIF/719-59-5.gif)
719-59-5
521 suppliers
$10.00/5g
![2-amino-5-chloro-alpha-methylbenzhydryl alcohol](/CAS/GIF/3158-98-3.gif)
3158-98-3
21 suppliers
$112.00/100mg
![2-Amino-5-chlorobenzophenone](/CAS/GIF/719-59-5.gif)
719-59-5
521 suppliers
$10.00/5g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
340 suppliers
$15.00/10g
![2-amino-5-chloro-alpha-methylbenzhydryl alcohol](/CAS/GIF/3158-98-3.gif)
3158-98-3
21 suppliers
$112.00/100mg
![Ethanone,1-(2-amino-5-chlorophenyl)-](/CAS/GIF/1685-19-4.gif)
1685-19-4
82 suppliers
inquiry
![PHENYLMAGNESIUM BROMIDE](/CAS/GIF/100-58-3.gif)
100-58-3
184 suppliers
$18.00/10ml
![2-amino-5-chloro-alpha-methylbenzhydryl alcohol](/CAS/GIF/3158-98-3.gif)
3158-98-3
21 suppliers
$112.00/100mg