2-AMINO-5-FLUOROACETOPHENONE synthesis
- Product Name:2-AMINO-5-FLUOROACETOPHENONE
- CAS Number:2343-25-1
- Molecular formula:C8H8FNO
- Molecular Weight:153.15
600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 °C for 36 hours.After the reaction, the temperature is lowered to 20-25 °C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 °C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 °C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.
887903-03-9
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2343-25-1
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$15.00/100mg
Yield: 91.4%
Reaction Conditions:
with hydrogenchloride;water at 50; for 36 h;Green chemistry;Temperature;Reagent/catalyst;
Steps:
8
600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 °C for 36 hours.After the reaction, the temperature is lowered to 20-25 °C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 °C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 °C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.
References:
Hangzhou Keyao Pharmaceutical Technology Co., Ltd.;Zhou Junming CN109384683, 2019, A Location in patent:Paragraph 0026-0042
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2343-25-1
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