ChemicalBook CAS DataBase List 2-BROMO-3-(CHLOROMETHYL)PYRIDINE

2-BROMO-3-(CHLOROMETHYL)PYRIDINE synthesis

6synthesis methods

Product Name:2-BROMO-3-(CHLOROMETHYL)PYRIDINE
CAS Number:89581-84-0
Molecular formula:C6H5Cl2N
Molecular Weight:162.02

18368-76-8
321 suppliers
$8.00/1g

89581-84-0
100 suppliers
$49.00/1g

Yield: 87.4%

Reaction Conditions:

with chlorine at 110; for 30 h;Temperature;

Steps:

2.A A. Chlorination:
480 g of 2-chloro-3-methylpyridine (99%) was added to the four-necked flask,Stirring,Warm up to 110°C, Continuously pass the chlorine gas of 40g/h for 30h,The reaction is over.Reagent distillation,The distillation tower is 1.5m high.The tower diameter is 0.02m.Glass spring packing(0.5*4mm),The reflux ratio is 3:1.Collect 94-96°C/400-pa fractions into 2-chloro-3-chloromethylpyridine 533g.99% purityYield 87.4%.

References:

Nanjing Hong Sun Biochemical Co., Ltd.;Chen Honglong;Mu Dengyou;Yue Ruikuan;Xue Yi;Zhong Jingsong CN107501171, 2017, A Location in patent:Paragraph 0029; 0030; 0038; 0039; 0040

42330-59-6 Synthesis