2-Chloro-4-ethoxy-1-nitrobenzene synthesis

8synthesis methods

Product Name:2-Chloro-4-ethoxy-1-nitrobenzene
CAS Number:5391-55-9
Molecular formula:C8H8ClNO3
Molecular Weight:201.607

64-17-5 Synthesis

64-17-5
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2106-50-5 Synthesis

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5391-55-9
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Yield:5391-55-9 96%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 40; for 7 h;

Steps:

11.1

Step 1: To a mixture of a (6.9 g, 39.3 mmol, 1.0 eq) and Cs2CO3 (26.0 g, 78.6 mmol, 2.0 eq) in DMF (150.0 mL) was added EtOH (2.7 g, 59.0 mmol, 1.5 eq) at rt. The resulting mixture was stirred at 40 °C for 7 h, cooled to room temperature, diluted with water (500 mL), and then extracted with EtOAc (100 mL x 2). The organic layers were concentrated and the residue purified by chromatography on silica gel (PE/EtOAc=20/1) to afford b (7.6 g, 96.0 %).

References:

WO2020/232375,2020,A1 Location in patent:Page/Page column 109