ChemicalBook CAS DataBase List 2-Chloro-4-fluoronitrobenzene

2-Chloro-4-fluoronitrobenzene synthesis

5synthesis methods

Product Name:2-Chloro-4-fluoronitrobenzene
CAS Number:2106-50-5
Molecular formula:C6H3ClFNO2
Molecular Weight:175.54

625-98-9 Synthesis

625-98-9
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2106-50-5
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$14.00/1g

Yield:2106-50-5 16.7%

Reaction Conditions:

with sulfuric acid;nitric acid in hexane;benzene

Steps:

37.a (a)
(a) 3-Chloro-4-nitrofluorobenzene m-Chlorofluorobenzene (240 g. 1.85 moles) is added to a mixture of sulfuric acid (185 g. 1.85 moles) and nitric acid (166 g., 1.85 moles) at -5° C. in 3.5 hours, stirred 13 hours, then benzene (200 ml.) and hexane (200 ml.) ae added. The extract is washed with water (1+300 ml.), sodium carbonate solution (1*300 ml.), and water (1*300 ml.), dried and the solvents removed. The residue is distilled to give 138 g. of mixed isomers. The 4-nitro isomer crystallizes and is filtered off to give 3-chloro-4-nitrofluorobenzene (51 g. 16.7%) m.p. 36°-38° C.

References:

Rohm and Haas Company US4330324, 1982, A

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