ChemicalBook CAS DataBase List 2-CHLORO-4-THIEN-2-YLPYRIMIDINE

2-CHLORO-4-THIEN-2-YLPYRIMIDINE synthesis

5synthesis methods

Product Name:2-CHLORO-4-THIEN-2-YLPYRIMIDINE
CAS Number:83726-75-4
Molecular formula:C8H5ClN2S
Molecular Weight:196.66

188290-36-0 Synthesis

188290-36-0
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1722-12-9 Synthesis

1722-12-9
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83726-75-4
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$45.00/10mg

Yield:83726-75-4 94%

Reaction Conditions:

Stage #1: thiophenewith n-butyllithium in diethyl ether at -40; for 0.5 h;
Stage #2: 2-chloropyrimidine in diethyl ether at -40; for 1 h;
Stage #3: with 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran at 20; for 0.416667 h;Further stages.;

References:

Bello, Angelica M.;Bende, Tanushree;Wei, Lianhu;Wang, Xiaoyang;Majchrzak-Kita, Beata;Fish, Eleanor N.;Kotra, Lakshmi P. [Journal of Medicinal Chemistry,2008,vol. 51,# 9,p. 2734 - 2743]

3934-20-1 Synthesis