2-chloro-9-methyl-9H-purine synthesis
- Product Name:2-chloro-9-methyl-9H-purine
- CAS Number:2346-73-8
- Molecular formula:C6H5ClN4
- Molecular Weight:168.58
1681-15-8
111 suppliers
$45.00/50mg
74-88-4
344 suppliers
$15.00/10g
2346-73-8
42 suppliers
$58.00/100mg
Yield:2346-73-8 37%
Reaction Conditions:
with potassium carbonate at 0; for 2 h;
Steps:
1 Step 1: Preparation of 2-chloro-9-methyl-9H-purine
A mixture of 2-chloro-9H-purine (200 mg, 1.30 mmol), K2CO3 (540 mg, 3.9 mmol), and iodomethane (370 mg, 2.6 mmol) was stirred at 0 °C for 2 h. Water (50 mL) was added and the mixture extracted with DCM (3 x 100 mL). The combined organic layers were washed with brine and concentrated in vacuo. The residue was purified by Prep-HPLC to afford the desired crude material (80 mg, 37%) as a white solid: MS (ES): m/z = 169 (M+H).
References:
WO2022/93552,2022,A2 Location in patent:Page/Page column 61