ChemicalBook CAS DataBase List 2-Cyanothiazole

2-Cyanothiazole synthesis

5synthesis methods

Product Name:2-Cyanothiazole
CAS Number:1452-16-0
Molecular formula:C4H2N2S
Molecular Weight:110.14

10200-59-6 Synthesis

10200-59-6
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$6.00/1g

1452-16-0
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$12.00/250mg

Yield: 69%

Reaction Conditions:

with ammonium acetate;phenyltrimethylammonium tribromide in acetonitrile at 20; for 21 h;

Steps:

General procedure: to a solution of 2-pyridinecarbaldehyde 1 (54 mg, 0.5 mmol) and ammonium acetate (385mg, 5.0 mmol) in MeCN )6ml), was added trimethylphenylammonium tribromide (376 mg, 1.0 mmol) at room temperature. after stirring for 21 h at rt, the reaction mixture was treated with 0.5 M aq Na2S2O3(10 ml), 1.0 M NaHCO3 )15 ml) and extracted with EtOAc (60 mL). The organic layer was washed with 0.5 M Na2S2O3 and successively washed with saturated aq.NaCl, and dried over MgSO4.

References:

Sayama, Shinsei [Heterocycles,2016,vol. 92,# 10,p. 1796 - 1802]