2-Cyclopentylthiazole-5-carbaldehyde synthesis
- Product Name:2-Cyclopentylthiazole-5-carbaldehyde
- CAS Number:1251104-23-0
- Molecular formula:C9H11NOS
- Molecular Weight:181.25
1494277-04-1
0 suppliers
inquiry
1251104-23-0
8 suppliers
inquiry
Yield: 87%
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 0 - 30; for 5 h;
Steps:
16.5 Step 5
To a mixture of 25e (2.1 g, 11.4 mmol) in DCM (50 mL) was added DMP (4.7 g, 12.5 mmol) in portions with stirring at 0 °C and then stirred at 30°C for 5 hours, before the mixture was quenched with Sat Na2S03 solution. After filtration and concentration in vacuo, and the resutling residue was purified using Si02 chromatography, eluting with petroleum ether: ethyl acetate (100/1-10/1) to provide25f (1.8 g, 87%). 1H NMR (CDC13) δ: 9.96 (s, 1H), 8.26 (s, 1H), 3.47 (q, J=7.7 Hz, 1H), 2.23 - 2.14 (m, 2H), 1.87 - 1.79 (m, 4H), 1.71 (s., 2H)
References:
MERCK SHARP & DOHME CORP.;YU, Wensheng;TONG, Ling;KOZLOWSKI, Joseph A.;SELYUTIN, Oleg;CHEN, Lei;KIM, Jae-Hun;SHA, Deyou;RIZVI, Razia;SHANKAR, Bandarpalle;HU, Bin;ZHONG, Bin;WAI, Dahai;HAO, Jinglai;WEI, Wei;JI, Tao;ZAN, Shuai WO2014/110705, 2014, A1 Location in patent:Page/Page column 85-86
1369899-95-5
4 suppliers
inquiry
1251104-23-0
8 suppliers
inquiry
3400-45-1
360 suppliers
$10.00/5g
1251104-23-0
8 suppliers
inquiry
3217-94-5
33 suppliers
$29.00/1 g
1251104-23-0
8 suppliers
inquiry
42202-73-3
21 suppliers
inquiry
1251104-23-0
8 suppliers
inquiry