2-Hydrazinopyrazine synthesis

Yield:54608-52-5 77.8%

Reaction Conditions:

with hydrazine hydrate;sodium carbonate at 120 - 130;

Steps:

Preparation of 2-hydrazinopyrazine (8)

The mixture of 2-chloropyrazine (7) (20.0 g, 0.175 mol),hydrazine hydrate (60 mL) and sodium carbonate (27.84 g,0.264 mol) was stirred for 2 h at 120-130 °C. After completionof the reaction that was checked by TLC, the reactionmass was allowed to cool at 50-60 °C and then water(60.0 mL) followed by isopropyl alcohol (IPA) (40.0 mL)were added. The reaction mass was maintained for 16 h at 0-3 °C and then the precipitated white solid was separatedby filtration. The wet solid was dried under vacuum at 45-50 °C to obtain desired 2-hydrazinopyrazine (14.8 g, 77.8%).1H NMR (400 MHz; CD3OD), d, ppm (J, Hz): 7.94-8.14(2H, m, Ar-H); 7.69 (1H, s, Ar-H). ESI-MS m/z (rel, %):111.07 (M+H⁺) (100). HRMS (FAB) Calc.: C4H6N4:110.059246; Found: 111.0592 [M+H⁺].

References:

Mannam, Madhava Rao;Devineni, Subba Rao;Pavuluri, Chandra Mouli;Chamarthi, Naga Raju;Kottapalli, Raja Sekhara P. [Phosphorus, Sulfur and Silicon and the Related Elements,2019,vol. 194,# 9,p. 922 - 932]