ChemicalBook CAS DataBase List 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine synthesis

4synthesis methods

Product Name:3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
CAS Number:486460-20-2
Molecular formula:C6H3F3N4
Molecular Weight:188.11

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

486460-20-2
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Yield: 90%

Reaction Conditions:

with triethylamine in toluene at 20; for 1 h;

Steps:

General Procedure for Compound 4 (4a, 4b, 4c)
General procedure: (10 mmole) of compound 3 was dissolved in 5 volume of toluene and to this was added (20 mmole) of triethylamine at ambient temperature, and stirred for 1hour. Progress of the reaction was monitored by TLC. After completion of the reaction the reaction mixture was poured on 25g of ice water layers were separated and the organic layer was washed with2X 10ml of cold water dried over sodium sulphate and concentrated to give compound 4 in excellent yield.

References:

Nitlikar, Lakshmikant H.;Darandale, Sunil N.;Shinde, Devanand B. [Letters in Organic Chemistry,2013,vol. 10,# 5,p. 348 - 352]

54608-52-5 Synthesis