ChemicalBook CAS DataBase List 2-METHOXY-3,5-DIBROMO-PYRIDINE

2-METHOXY-3,5-DIBROMO-PYRIDINE synthesis

7synthesis methods

Product Name:2-METHOXY-3,5-DIBROMO-PYRIDINE
CAS Number:13472-60-1
Molecular formula:C6H5Br2NO
Molecular Weight:266.92

13472-85-0 Synthesis

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13472-60-1
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Yield:-

Reaction Conditions:

with bromine;sodium acetate in acetic acid at 20 - 80;

Steps:

10.1
Step 1: To 5-bromo-2-methoxypyridine (0.564 g, 3.0 mmol) and sodium acetate (0.246 g, 3.0 mmol) in acetic acid (3 mL) was added bromine (0.27 mL, 5.25 mmol), and the mixture was stirred at 80° C. for 3 hours, and then at room temperature overnight. The mixture was diluted with H₂O and extracted with EtOAc, and the combined organic layers were washed with saturated aqueous Na₂CO₃ and saturated aqueous Na₂S₂O₃. The organic layer was concentrated and dried under high vacuum to give 3,5-dibromo-2-methoxy-pyridine.

References:

AMIRA PHARMACEUTICALS, INC. US2010/81673, 2010, A1 Location in patent:Page/Page column 14