ChemicalBook CAS DataBase List 2'-METHYL[1,1'-BIPHENYL]-2-OL

2'-METHYL[1,1'-BIPHENYL]-2-OL synthesis

6synthesis methods

Product Name:2'-METHYL[1,1'-BIPHENYL]-2-OL
CAS Number:77897-02-0
Molecular formula:C13H12O
Molecular Weight:184.23

132-64-9 Synthesis

132-64-9
342 suppliers
$5.00/10g

75-24-1
156 suppliers
$54.50/100ml

77897-02-0
31 suppliers
$47.00/100mg

Yield:77897-02-0 60%

Reaction Conditions:

with bis(1,5-cyclooctadiene)nickel ⁽⁰⁾;sodium t-butanolate;1,3-bis(cyclohexyl)imidazolium tetrafluoroborate in toluene at 80; for 18 h;Sealed tube;Glovebox;Inert atmosphere;

Steps:

III. Typical Procedure for Ni/ICy-Catalyzed Methylation of Anisoles (Tables 1 and 2)

General procedure: Ni(cod)₂ (3.4 mg, 0.025 mmol), ICy·HBF₄ (4.0 mg, 0.025 mmol), NaO^tBu (48 mg, 0.50 mmol) and toluene (0.50 mL) were added to a 10 mL-sample vial with a Teflon-sealed screwcap in a glovebox filled with nitrogen. The resulting mixture was stirred at room temperature for 3 min. An aryl methyl ether (0.25 mmol) in toluene (0.50 mL) and AlMe₃ (1.8 M in toluene solution, 0.14 mL, 0.25 mmol) were then added to the vial and the screw cap was closed. The contents of the vial were stirred at 80 °C for 6 or 18 h. The reaction mixture was cooled to room temperature, and the crude mixture was then treated with EtOH. The resulting mixture was filtered through a pad of silica gel, and then analyzed by GC. The filtrate was concentrated in vacuo to give a residue, which was purified by flash column chromatography over silica gel.

References:

Morioka, Toshifumi;Nishizawa, Akihiro;Nakamura, Keisuke;Tobisu, Mamoru;Chatani, Naoto [Chemistry Letters,2015,vol. 44,# 12,p. 1729 - 1731] Location in patent:supporting information

95-56-7 Synthesis