![](/CAS/20180527/GIF/3805-10-5.gif)
2-methyl-2-phenylpropanal synthesis
- Product Name:2-methyl-2-phenylpropanal
- CAS Number:3805-10-5
- Molecular formula:C10H12O
- Molecular Weight:148.2
![2-methyl-2-phenyl-propan-1-ol](/CAS/GIF/2173-69-5.gif)
2173-69-5
60 suppliers
$40.00/100mg
![2-methyl-2-phenylpropanal](/CAS/20180527/GIF/3805-10-5.gif)
3805-10-5
15 suppliers
inquiry
Yield: 91.6%
Reaction Conditions:
with sulfur trioxide pyridine complex;triethylamine in dimethyl sulfoxide at 20; for 2.5 h;
Steps:
82
To a solution of 2-methyl-2-phenyl-propan-1-ol (13.3 g, 87.0 mmol) in DMSO (150 mL) was added triethylamine (24.7 mL, 178.0 mmo) at rt, followed by pyridine sulfuric oxide (28.6 g, 180.0 mmol). The mixture was stirred for 2.5 h at rt. Water was added and the resulting mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the crude product 2-methyl-2-phenyl- propionaldehyde (12.0 mg, 91.6 %), which was used to the next step without further purification.
References:
NOVO NORDISK A/S WO2008/84044, 2008, A1 Location in patent:Page/Page column 117
![Benzenemethanol, α-(1-bromo-1-methylethyl)-](/CAS/20210305/GIF/83569-58-8.gif)
83569-58-8
0 suppliers
inquiry
![2-methyl-2-phenylpropanal](/CAS/20180527/GIF/3805-10-5.gif)
3805-10-5
15 suppliers
inquiry
201230-82-2
1 suppliers
inquiry
![2-Phenyl-1-propene](/CAS/GIF/98-83-9.gif)
98-83-9
294 suppliers
$10.00/25mL
![2-methyl-2-phenylpropanal](/CAS/20180527/GIF/3805-10-5.gif)
3805-10-5
15 suppliers
inquiry
![3-PHENYLBUTYRALDEHYDE](/CAS/GIF/16251-77-7.gif)
16251-77-7
54 suppliers
$14.14/250mgs:
![2-Phenylisobutyric acid](/CAS/GIF/826-55-1.gif)
826-55-1
291 suppliers
$6.00/10g
![2-methyl-2-phenylpropanal](/CAS/20180527/GIF/3805-10-5.gif)
3805-10-5
15 suppliers
inquiry