ChemicalBook CAS DataBase List 2-methyl-2-phenylpropanal

2-methyl-2-phenylpropanal synthesis

13synthesis methods

Product Name:2-methyl-2-phenylpropanal
CAS Number:3805-10-5
Molecular formula:C10H12O
Molecular Weight:148.2

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Yield: 91.6%

Reaction Conditions:

with sulfur trioxide pyridine complex;triethylamine in dimethyl sulfoxide at 20; for 2.5 h;

Steps:

82
To a solution of 2-methyl-2-phenyl-propan-1-ol (13.3 g, 87.0 mmol) in DMSO (150 mL) was added triethylamine (24.7 mL, 178.0 mmo) at rt, followed by pyridine sulfuric oxide (28.6 g, 180.0 mmol). The mixture was stirred for 2.5 h at rt. Water was added and the resulting mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the crude product 2-methyl-2-phenyl- propionaldehyde (12.0 mg, 91.6 %), which was used to the next step without further purification.

References:

NOVO NORDISK A/S WO2008/84044, 2008, A1 Location in patent:Page/Page column 117

34713-70-7 Synthesis