2-METHYL-4-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID synthesis
- Product Name:2-METHYL-4-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
- CAS Number:32002-72-5
- Molecular formula:C11H9NO2S
- Molecular Weight:219.26
32043-95-1
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32002-72-5
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Yield:32002-72-5 99.3%
Reaction Conditions:
with potassium hydroxide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate;ethanol;water;
Steps:
R.2.2 2)
2) 4-Phenyl-2-methyl-5-thiazolecarboxylic acid A mixture of 4.00 g of compound B and 1.81 g of potassium hydroxide in 40 cc of ethanol and 10 cc of water was heated under reflux for 3 hours. After cooling, the solvent was distilled off under reduced pressure and ice water was added to the residue, followed by washing with n-hexane. The aqueous layer was acidified with 1N HCl and the crystals thus precipitated were collected by filtration, washed with water, and then dried to obtain 3.53 g of 4-phenyl-2-methyl-5-thiazolecarboxylic acid. Yield: 99.3%.
References:
EP761658,1997,A1
94-02-0
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32002-72-5
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55919-47-6
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62-55-5
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32002-72-5
25 suppliers
$45.00/25mg