![](/CAS/GIF/21203-68-9.gif)
2-Methyl-5-nitropyridine synthesis
- Product Name:2-Methyl-5-nitropyridine
- CAS Number:21203-68-9
- Molecular formula:C6H6N2O2
- Molecular Weight:138.12
![2-Methyl-5-nitropyridine 2-Methyl-5-nitropyridine](/NewsImg/2023-11-08/6383505362795823837389000.jpg)
![DIETHYL (5-NITROPYRIDIN-2-YL)MALONATE](/CAS/GIF/60891-70-5.gif)
60891-70-5
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![2-Methyl-5-nitropyridine](/CAS/GIF/21203-68-9.gif)
21203-68-9
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Yield:21203-68-9 83%
Reaction Conditions:
with sulfuric acid;water at 100; for 2 h;
Steps:
28
Reference Example 28: 5-Nitro-2-methyl pyridine. To 2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester (12.0 g, 42.5 mmol) was added cold aq. 20% sulfuric acid (120 mL) and the mixture was heated to 1000C for 2h. The cooled reaction was added to cold dilute sodium hydroxide solution and the pH adjusted to pH -10. The organics were extracted with dichloromethane (x 4), then the combined organic phases were dried over sodium sulfate. The filtrate was concentrated to afford 2-methyl-5-nitro pyridine (5.0 g, 83 %) as a brown solid.
References:
F2G LTD WO2008/62182, 2008, A1 Location in patent:Page/Page column 117
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109-06-8
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![2-Methyl-5-nitropyridine](/CAS/GIF/21203-68-9.gif)
21203-68-9
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![2-Methyl-5-nitropyridine](/CAS/GIF/21203-68-9.gif)
21203-68-9
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![Acetone](/CAS/GIF/67-64-1.gif)
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![2-Methyl-5-nitropyridine](/CAS/GIF/21203-68-9.gif)
21203-68-9
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$8.00/1g
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