2-Pyridinecarboxylicacid,5,6-dimethyl-(9CI) synthesis

Yield:83282-49-9 80%

Reaction Conditions:

with hydrogenchloride;waterHeating / reflux;

Steps:

91.a

5,6-Dimethylpicolinic acid: 5,6-dimethylpicolinonitrile (example 91b) was refluxed in concentrated HCl (15 mL) overnight. The solvent was evaporated and the solid residue was co-evaporated several times with EtOH. Drying provided 453 mg of 5,6-Dimethylpicolinic acid (80%) as a white solid. MS (M+H, 152.1).

References:

US2005/84506,2005,A1 Location in patent:Page/Page column 52