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ChemicalBook CAS DataBase List 2-(Trifluoromethyl)pyridine

2-(Trifluoromethyl)pyridine synthesis

4synthesis methods
-

Yield:368-48-9 96%

Reaction Conditions:

with copper in N,N-dimethyl-formamide at 0 - 80; for 4 h;Inert atmosphere;

Steps:

6 Example 6: Preparation of 2-trifluoromethylpyridine

2-bromopyridine (1.58 g, 0.01 mol) was added to a 100 ml three-necked flask under N2 protection.25 ml of DMF, Cu powder (1.92 g, 0.03 mol), stirring was started, and the ice water bath was cooled to 0-5 °C. add Umemoto reagent (8.76g, 0.02mol).After stirring for 1 h in an ice water bath, the mixture was further heated to 80 ° C for 3 h.The reaction solution was subjected to 19F NMR analysis using OTf as an internal standard, and the yield was 96%.

References:

CN108239021,2018,A Location in patent:Paragraph 0060-0062

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